Description
Trident Triple Combination Sheep Drench: Three-Way Resistance Control in One Shot
Trident Triple Combination Drench for Sheep controls sensitive and resistant strains of gastrointestinal nematodes in sheep using three actives from separate chemical families: 40 g/L Levamisole Hydrochloride (imidazothiazole), 25 g/L Albendazole (benzimidazole), and 1 g/L Moxidectin (macrocyclic lactone). This combination targets worms with single, dual, or triple resistance to macrocyclic lactones (including abamectin-resistant strains), benzimidazoles, imidazothiazoles (levamisole/morantel), and monepantel. Zoetis Australia developed Trident specifically to address the growing challenge of drench resistance in Australian sheep operations.
Trident delivers broad-spectrum control across eight parasite species, including immature L4 larvae of key worms such as Barber’s pole worm and small brown stomach worm. Because each active ingredient attacks parasites via a different mechanism, Trident significantly delays the development of further resistance. It also provides 14 days of persistent reinfestation protection against macrocyclic lactone-sensitive strains of Barber’s pole worm and small brown stomach worm.
What Parasites Does Trident Control?
Trident controls sensitive and resistant strains of these gastrointestinal parasites (including L4 larvae where marked):
| Parasite | Scientific Name |
|---|---|
| Barber’s pole worm* | Haemonchus contortus |
| Stomach hair worm* | Trichostrongylus axei |
| Black scour worm* | T. colubriformis, T. rugatus, T. vitrinus |
| Small brown stomach worm* | Teladorsagia circumcincta, T. trifurcata, T. davtiani |
| Small intestinal worm* | Cooperia spp., Cooperia punctata |
| Thin-necked intestinal worm | Nematodirus spp., N. spathiger |
| Nodule worm | Oesophagostomum spp., O. columbianum |
| Whipworm | Trichuris ovis |
*Including immature L4 larvae
What Makes Trident Different From a Single-Active Drench?
Single-active drenches apply pressure through one mechanism only, which accelerates resistance selection. Trident uses three proven chemical families simultaneously, so worms must overcome three separate attack pathways at once. Research shows that triple combination drenches, such as Trident, can significantly delay the onset of drench resistance when used as part of a sound worm management programme. Consult your veterinarian or animal health adviser to build a resistance management plan suited to your property.
Trident Triple Combination Sheep Drench Formulation at a Glance:
| Active Ingredient | Chemical Family | Common Name |
|---|---|---|
| Moxidectin | Macrocyclic lactone | Mectin drench |
| Levamisole | Imidazothiazole | Clear drench |
| Albendazole | Benzimidazole | White drench |
Avoid drench resistance: A complete guide to effective sheep drenching

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